We study repair of diseased (transplant) organs by use of cellular therapies such as mesenchymal stem cells. These cells can suppress devastating immune responses against injured organs and stimulate cells within the organs to proliferate and differentiate. Furthermore, we are working on the generation of miniature kidney tissue in the laboratory, so called organoids, from primitive stem cells, which may one day be implanted in the diseased kidney. The aim of these studies is to improve the quality of transplant organs and to repair diseased organs to delay the need for transplantation.
For more information on tissue repair and cell therapy applications within the Rotterdam Transplantation laboratory please contact:
Martin Hoogduijn, PhD