The Rotterdam Transplantation Lab

Specialism

At the laboratory we have a wide range of assays to monitor pathways of donor directed reactivity.
The aim of this translational work is to titrate the immunosuppressive burden on our patients in such a way that side-effects (infections, malignancies, cardiovascular events) are kept at a minimum while at the same time rejection processes are prevented.

Tissue regeneration of injured and marginal donor kidneys has become a major goal. We are part of the international consortium MEPEP that studies the Role of mesenchymal stem cells to regenerate renal graft function after ischemia reperfusion injury using normothermic ex-situ machine perfusion in pig transplantation model.

In our tissue repair and injury research we also study the potential of mesenchymal stem cell vesicles and iPS-derived kidney organoids .

Cell damage due to the transplantation procedure or allograft rejection is accompanied by the release of donor-derived cell-free DNA (dd-cfDNA), nucleosomes, extracellular vesicles, and more in the patient’s blood. To exploit blood as a liquid biopsy we are developing and implementing novel technologies in the fields of dd-cfDNA, nucleosomes, extracellular vesicles and antibody based detection devices to diagnose kidney transplant rejection.

Our team

Carla-Baan-Prof

Carla C. Baan, Professor PhD

M.J

Martin J. Hoogduijn, PhD

K.-Boer

Karin Boer, PhD

Ana-Merino,-PhD

Ana Merino, PhD

Nicole-M

Nicole M. van Besouw, PhD

N.H.R

Nicolle H.R. Litjens, PhD

Wenda-Verschoor

Wenda Verschoor

Amy van der List, MSc

Amy van der List, MSc

Wouter-W

Wouter W. Woud, MSc

Aleixandra-Mendoza,-MSc

Aleixandra Mendoza, MSc

Marieke-van-der-Zwan-MD-MSc

Marieke van der Zwan, MD MSc

Jeroen-Verhoeven,-MD-MSc

Jeroen G.H.P. Verhoeven, MD MSc

Anusha-Shankar-MD-MSc

Anusha Shankar, MD MSC

Jesus-M

Jesus Sierra, MSc

Ronella-de-Kuiper

Ronella de Kuiper, BSc

Sander-Korevaar

Sander Korevaar, BSc

Marjolein-Dieterich-BSc

Marjolein Dieterich, BSc

Derek-Reijerkerk

Derek Reijerkerk

Rens-Kraaijeveld,-BSc

Rens Kraaijeveld, BSc

Hector Tejeda Mora, MSc

Hector Tejeda Mora, MSC

Zhaoyu Du Website Photo

Steven Du, MSC

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Fabiany da Costa Gonçalves, PhD

Olivia Lee

Olivia Lee, MSC

Qian Niu, MSC

Qian Niu, MSC

Sharoefa Abdoelaziz

Sharoefa Abdoelaziz